| Bioactivity | AKR1C2/3-IN-1 (compound 3a) is a potent AKR1C2 and AKR1C3 inhibitor with IC50 values of 90, 50 nM, respectively. AKR1C2/3-IN-1 can be used as a radiation sensitizer and as a potentiator of chemotherapy cytotoxicity[1]. |
| Target | IC50: 90 nM (AKR1C2); 50 nM (AKR1C3) |
| Formula | C14H15NO4 |
| Molar Mass | 261.27 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Jonnalagadda S, et al. Coumarin-based Aldo-Keto Reductase Family 1C (AKR1C) 2 and 3 Inhibitors. ChemMedChem. 2024 Jul 8:e202400081. |