| Bioactivity | AIMP2-DX2-IN-1 (Compound 35) is a potent AIMP2-DX2 inhibitor with an IC50 of 0.1063 μM[1]. |
| Target | IC50: 0.1063 μM (AIMP2-DX2) |
| Invitro | AIMP2-DX2-IN-1 (Compound 35) (0-1 μM, 96 h) shows inhibitory activity against A549 and H460 cells without toxicity for normal cells[1].AIMP2-DX2-IN-1 showes very poor metabolic stability and good plasma stability in both human and mouse, and CYP inhibition need to be improved[1]. Cell Viability Assay[1] Cell Line: |
| Name | AIMP2-DX2-IN-1 |
| CAS | 848256-17-7 |
| Formula | C23H21NO3 |
| Molar Mass | 359.42 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Lee B, et al. Discovery of benzodioxane analogues as lead candidates of AIMP2-DX2 inhibitors. Bioorg Med Chem Lett. 2022 Jul 13;73:128889. |