| Bioactivity | AI-10-49 is an inhibitor of leukemic oncoprotein CBFβ-SMHHC. AI-10-49 inhibits the binding of CBFβ-SMMHCto the RUNX1 Runt domain with IC50 value of 0.26 μM. AI-10-49 can be used for the research of leukemia[1]. | ||||||||||||
| Invitro | AI-10-49 inhibits the binding of CBFβ-SMMHCto theRUNX1 Runt domain with IC50 value of 0.26 μM[1].AI-10-49 (1 μM; 3, 6, 12 hours) has selectivity for inhibiting CBFβ-SMMHC binding to RUNX1[1]. Western Blot Analysis[1] Cell Line: | ||||||||||||
| In Vivo | AI-10-49 (200 mg/kg; per day) delays leukemia progression in mice[1]. Animal Model: | ||||||||||||
| Name | AI-10-49 | ||||||||||||
| CAS | 1256094-72-0 | ||||||||||||
| Formula | C30H22F6N6O5 | ||||||||||||
| Molar Mass | 660.52 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Anuradha Illendula, et al. Chemical biology. A small-molecule inhibitor of the aberrant transcription factor CBFβ-SMMHC delays leukemia in mice. Science. 2015 Feb 13;347(6223):779-84. |
AI-10-49
CAS: 1256094-72-0 F: C30H22F6N6O5 W: 660.52
AI-10-49 is an inhibitor of leukemic oncoprotein CBFβ-SMHHC. AI-10-49 inhibits the binding of CBFβ-SMMHCto the RUNX1 R
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