| Bioactivity | AGI-43192 is a potent inhibitor of methionine adenosyltransferase 2A (MAT2A). AGI-43192 is a potent, but limited brain-penetrant compound. AGI-43192 has the potential for exploring the effects of SAM modulation in the central nervous system (CNS) and research of cancer disease[1]. | ||||||||||||
| Name | AGI-43192 | ||||||||||||
| CAS | 2377491-54-6 | ||||||||||||
| Formula | C23H16ClF3N6O | ||||||||||||
| Molar Mass | 484.86 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
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| Reference | [1]. Li M, et al. Leveraging Structure-Based Drug Design to Identify Next-Generation MAT2A Inhibitors, Including Brain-Penetrant and Peripherally Efficacious Leads. J Med Chem. 2022;65(6):4600-4615. |
AGI-43192
CAS: 2377491-54-6 F: C23H16ClF3N6O W: 484.86
AGI-43192 is a potent inhibitor of methionine adenosyltransferase 2A (MAT2A). AGI-43192 is a potent, but limited brain-p
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