| Bioactivity | AG311 is an anticancer and antimetastatic agent. AG311 induces rapid necrosis in numerous cancer cell lines[1]. |
| Invitro | AG311 (0-30 μM; 48 h) 显示对癌细胞的细胞毒性[1]。AG311 (10-40 μM; 0-150 min) 选择性诱导乳腺癌细胞膜透性 (与 HUVECs 相比)[1]。Ag311 (25 μm;20 min)诱导MDA-MB-435细胞坏死，缺乏凋亡分子标志物[1]。AG311 (25 μM; 20 min) 影响 MDA-MB-435 细胞钙稳态和质膜去极化[1]。AG311 (5-20 μM) 诱导 MDA-MB-435 细胞线粒体膜快速改变和线粒体功能障碍[1]。AG311 (0-14 μM; 30 h) 抑制乳腺癌细胞迁移[1]。 Cell Viability Assay[1] Cell Line: |
| In Vivo | AG311 (23 mM; intratumoral; once daily for 2 days) 在小鼠中增加癌细胞坏死[1]。AG311 (45 mg/kg; i.p.; twice weekly for 30 days) 抑制小鼠肿瘤生长和肺转移[1]。 Animal Model: |
| Name | AG311 |
| CAS | 1126602-42-3 |
| Formula | C17H15N5S |
| Molar Mass | 321.40 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Bastian A, et al. A small molecule with anticancer and antimetastatic activities induces rapid mitochondrial-associated necrosis in breast cancer. J Pharmacol Exp Ther. 2015 May;353(2):392-404. |