| Bioactivity | AFP464 (dihydrochloride) (NSC710464 (dihydrochloride)) is the hydrochloride form of AFP464 and is a potent HIF-1α inhibitor with an IC50 value of 0.25 μM. It is also an activator of aryl hydrocarbon receptor (AhR). | ||||||||||||
| Name | AFP464 dihydrochloride | ||||||||||||
| Formula | C22H25Cl2F3N4O3 | ||||||||||||
| Molar Mass | 521.36 | ||||||||||||
| Appearance | 固体 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
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| Reference | [1]. Terzuoli E1, Aminoflavone, a ligand of the aryl hydrocarbon receptor, inhibits HIF-1alpha expression in an AhR-independent fashion. Cancer Res. 2010 Sep 1;70(17):6837-48. |
AFP464 dihydrochloride
CAS: F: C22H25Cl2F3N4O3 W: 521.36
AFP464 (dihydrochloride) (NSC710464 (dihydrochloride)) is the hydrochloride form of AFP464 and is a potent HIF-1α inhib
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