| Bioactivity | AF40431, the first reported small-molecule ligand of sortilin, has an IC50 of 4.4 µM and a Kd of 0.7 µM . AF40431 is bound in the neurotensin-binding site of sortilin[1]. | ||||||||||||
| Target | IC50: 4.4 µM (sortilin)Kd: 0.7 µM (sortilin) | ||||||||||||
| Name | AF40431 | ||||||||||||
| CAS | 181125-92-8 | ||||||||||||
| Formula | C17H21NO5 | ||||||||||||
| Molar Mass | 319.35 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Andersen JL, et al. Identification of the first small-molecule ligand of the neuronal receptor sortilin and structure determination of the receptor-ligand complex. Acta Crystallogr D Biol Crystallogr. 2014 Feb;70(Pt 2):451-60. |