| Bioactivity | AF38469 is a selective, orally bioavailable Sortilin inhibitor with an IC50 value of 330 nM. | ||||||||||||
| Target | IC50:330 nM (Sortilin) | ||||||||||||
| In Vivo | AF38469 (1 mg/kg; i.v.) has a low volume of distribution (blood volume of 0.7 L/kg) and low clearance (4.8 L/h/kg), and a half-life (t1/2) of 1.2 h in rat[1]. | ||||||||||||
| Name | AF38469 | ||||||||||||
| CAS | 1531634-31-7 | ||||||||||||
| Formula | C15H11F3N2O3 | ||||||||||||
| Molar Mass | 324.25 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Schroder TJ, et al. The identification of AF38469: an orally bioavailable inhibitor of the VPS10P family sorting receptor Sortilin. Bioorg Med Chem Lett. 2014 Jan 1;24(1):177-80. |