| Bioactivity | APE-IN-1 is a potent inhibitor of APE with IC50 value of 89 nM. APE-IN-1 can be used for early diagnosis and drug research of AD[1]. |
| Invitro | APE-IN-1 (5-500 nM; 24 hours) does not change cell viability in L929 normal fibroblasts at different concentrations[1]. Cell Viability Assay Cell Line: |
| Name | AEP-IN-1 |
| Formula | C18H27N3O3 |
| Molar Mass | 333.43 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Lorenzo Calugi, et al. Modular synthesis of 2,4-diaminoanilines as CNS drug-like non-covalent inhibitors of asparagine endopeptidase. Bioorg Med Chem. 2022 Jun 1;63:116746. |