| Bioactivity | ADR58 is a highly potent and selective human oncostatin M (OSM) antagonist, which can prevent the binding of OSM to the gp130 receptor and specifically antagonize OSM-mediated signaling. ADR58 can be used in the research of rheumatoid arthritis related diseases[1]. |
| Invitro | ADR58(0-3 μM) 可以以剂量依赖性方式阻断人 OSM 激活 HepG2 B6 细胞中分泌的胎盘碱性磷酸酶报告基因的能力，其 IC50 值为 100 nM[1]。ADR58(0-3 μM) 可以以剂量依赖性方式阻断人 OSM 与 gp130 受体的结合，表观 IC50为 1 μM，并能够抑制 OSM 诱导的报告基因激活[1]。 |
| Name | ADR58 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. A Rhodes, et al. The generation and characterization of antagonist RNA aptamers to human oncostatin M. J Biol Chem. 2000 Sep 15;275(37):28555-61. |