| Bioactivity | ADAMTS-5-IN-3 (Example 37-2) is a potent inhibitor of ADAMTS-5 and ADAMTS-4 with IC50s of 8 and 12 nM, respectively. ADAMTS-5-IN-3 can be used for the research of diseases involving degradation of cartilage or disruption of cartilage homeostasis, in particular osteoarthrosis and/or rheumatoid arthritis[1]. |
| Name | ADAMTS-5-IN-3 |
| CAS | 2688733-96-0 |
| Formula | C20H23Cl2N3O3 |
| Molar Mass | 424.32 |
| Appearance | Solid |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | 4°C, sealed storage, away from moisture and light *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light) |
| Reference | [1]. Dong Liu, et al. Adamts inhibitors, preparation methods and medicinal uses thereof. WO2021158626A1. |
ADAMTS-5-IN-3
CAS: 2688733-96-0 F: C20H23Cl2N3O3 W: 424.32
ADAMTS-5-IN-3 (Example 37-2) is a potent inhibitor of ADAMTS-5 and ADAMTS-4 with IC50s of 8 and 12 nM, respectively. ADA
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