| Bioactivity | AD 0261 is a radical scavenger which displays strong inhibitory action on the generation of lipid peroxides and superoxide anions. |
| Invitro | AD 0261 displays strong inhibitory action on the generation of lipid peroxides (IC50=0.022 μM) and superoxide anions (IC50= 0.9-4.0 μM). AD 0261 inhibits cytokine release and/or production from PHA-P-stimulated lymphocytes in a dose-dependent manner. AD 0261 inhibits all parameters which are indicative of lymphocyte activation with 50% inhibition being achieved in a range of 1-10 μM. AD 0261 suppresses ornithine decarboxylase activity, the IC50 value being around 1.0 μM[1]. |
| Name | AD 0261 |
| CAS | 145600-69-7 |
| Formula | C27H31F2N3O |
| Molar Mass | 451.55 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. M. Sugiura, et al. Effect of the novel radical scavenger AD0261 on lymphocyte activation. Information Research. Agents and Actions. August 1994, Volume 41, Supplement 2, pp C216-C218. |