| Bioactivity | Dual AChE-MAO B-IN-5, indanone derivative, is a potent dual AChE/MAO-B inhibitior with IC50 values of 0.0224, 0.0412, and 0.1116 μM for AChE, MAO-B and MAO-A, respectively. Dual AChE-MAO B-IN-5 has antioxidant activity and prevents β-amyloid plaque aggregation. Dual AChE-MAO B-IN-5 can be used for Alzheimer’s disease (AD) research[1]. |
| Invitro | Dual AChE-MAO B-IN-5 (conpound D29; 0.1-1 μM) 具有抗氧化活性，其 IC50 值为 0.188 μM[1]。Dual AChE-MAO B-IN-5 (0.1-1 μM) 增加胆碱能活性并防止 β-淀粉样斑块的形成，0.1 μM 和 1 μM 的抑制率分别为 82.748% 和 71.891%[1]。 |
| Name | AChE/MAO-IN-2 |
| Formula | C23H26N2O3 |
| Molar Mass | 378.46 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Sağlık BN, et, al. Design, Synthesis, and In Vitro and In Silico Approaches of Novel Indanone Derivatives as Multifunctional Anti-Alzheimer Agents. ACS Omega. 2022 Dec 7;7(50):47378-47404. |