| Bioactivity | AChE/MAO-IN-1 (Compound D28) is a potent AChE, MAO-A and MAO-B inhibitor with IC50s of 0.0248, 0.0409 and 0.1108 μM against human AChE, MAO-B and MAO-A, respectively[1]. |
| Invitro | AChE/MAO-IN-1 (Compound D28) 具有抗氧化活性，在 DPPH 自由基清除活性测试中的 IC50 为 0.210 ± 0.010 μM[1]。AChE/MAO-IN-1 抑制 β-淀粉样蛋白 1-42 (Aβ42)，IC50 为 0.1467 ± 0.0053 μM[1]。AChE/MAO-IN-1 (24 h) 对 NIH/3T3 细胞具有低细胞毒性 (IC50: 6.5162 ± 0.1750 μM)[1]。AChE/MAO-IN-1 可以高效地结合 MAO-A 的活性位点[1]。 Cell Cytotoxicity Assay[1] Cell Line: |
| Name | AChE/MAO-IN-1 |
| Formula | C23H26N2O3 |
| Molar Mass | 378.46 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Sağlık BN, et al. Design, Synthesis, and In Vitro and In Silico Approaches of Novel Indanone Derivatives as Multifunctional Anti-Alzheimer Agents. ACS Omega. 2022 Dec 7;7(50):47378-47404. |