AChE/BuChE-IN-2_product_DataBase

Bioactivity	AChE/BuChE-IN-2 (Compound 5f) is an orally active AChE and BuChE inhibitor with IC50 values of 0.72 μM and 0.16 μM, respectively. AChE/BuChE-IN-2 shows a non-competitive inhibition with AChE and shows potent self-induced β-amyloid (Aβ) aggregation inhibition with an IC50 of 62.52 μM. AChE/BuChE-IN-2 can cross the BBB[1].
Target	IC50: 0.16 μM (BuChE), 0.72 μM (AChE), 62.52 μM (Aβ aggregation)
In Vivo	AChE/BuChE-IN-2 (Compound 5f) (20 μmol/kg) significantly ameliorates the cognitive performances of scopolamine-treated ICR mice[1].
Name	AChE/BuChE-IN-2
CAS	1946008-31-6
Formula	C20H18N2O2
Molar Mass	318.37
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Luo W, et al. Synthesis, in vitro and in vivo biological evaluation of novel graveolinine derivatives as potential anti-Alzheimer agents. Bioorg Med Chem. 2020 Jan 1;28(1):115190.

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