| Bioactivity | AChE/BChE/BACE-1-IN-1 (Compound 4k) is an orally active inhibitor of AChE, BChE, and BACE-1 with IC50 values of 0.058, 0.082 and 0.115 μM against hAChE, hBChE and hBACE-1, respectively. AChE/BChE/BACE-1-IN-1 shows considerable PAS-AChE binding capability, excellent brain permeation, potential disassembly of Aβ aggregates, and neuroprotective activity against Aβ-induced stress. AChE/BChE/BACE-1-IN-1 has remarkable antioxidant potential[1]. |
| Target | IC50: 0.058 μM (hAChE), 0.082 μM (hBChE), 0.115 μM (hBACE-1) |
| In Vivo | AChE/BChE/BACE-1-IN-1 (Compound 4k) (0-10 mg/kg; p.o.) ameliorates cognitive dysfunction against the scopolamine-induced amnesia model in the Y-maze test[1]. |
| Name | AChE/BChE/BACE-1-IN-1 |
| CAS | 1321361-13-0 |
| Formula | C19H21F3N2O |
| Molar Mass | 350.38 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Choubey PK, et al. Design, synthesis, and multitargeted profiling of N-benzylpyrrolidine derivatives for the treatment of Alzheimer's disease. Bioorg Med Chem. 2020 Nov 15;28(22):115721. |
AChE/BChE/BACE-1-IN-1
CAS: 1321361-13-0 F: C19H21F3N2O W: 350.38
AChE/BChE/BACE-1-IN-1 (Compound 4k) is an orally active inhibitor of AChE, BChE, and BACE-1 with IC50 values of 0.058, 0
Sales Email：peptidedb@qq.com
This product is for research use only, not for human use. We do not sell to patients.