| Bioactivity | AChE/BChE-IN-9 (Compound 7a) is a potent, orally active AChE and BChE inhibitor with IC50 values of 5.74 μM and 14.05 μM against hAChE and eqBChE, respectively. AChE/BChE-IN-9 is also an efficacious antioxidant with an IC50 of 57.35 μM. AChE/BChE-IN-9 is able to chelate iron and modulates aggregation of amyloid β1-42. AChE-IN-16 can cross the BBB[1]. |
| Target | IC50: 5.74 μM (AChE), 14.05 μM (BChE) |
| In Vivo | AChE/BChE-IN-9 (Compound 7a) (0-25 mg/kg) improves spatial memory in cognitive deficit mice[1]. |
| Name | AChE/BChE-IN-9 |
| CAS | 2761542-55-4 |
| Formula | C20H19N3O4 |
| Molar Mass | 365.38 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Singh YP, et al. Design, synthesis and biological evaluation of novel naturally-inspired multifunctional molecules for the management of Alzheimer's disease. Eur J Med Chem. 2020 Jul 15;198:112257. |
AChE/BChE-IN-9
CAS: 2761542-55-4 F: C20H19N3O4 W: 365.38
AChE/BChE-IN-9 (Compound 7a) is a potent, orally active AChE and BChE inhibitor with IC50 values of 5.74 μM and 14.05
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