| Bioactivity | AChE-IN-62 (Compound 1) is an effective mixed and selective acetylcholinesterase (AChE) inhibitor with an IC50 value of 0.421 μM. AChE-IN-62 exhibits excellent blood-brain barrier permeability and neuroprotective effects. Additionally, AChE-IN-62 can inhibit the aggregation of Aβ1?42 with an IC50 value of 44.64 μM. AChE-IN-62 is also an effective multi-target-directed ligand (MTDL) that can be utilized in the research of Alzheimer's disease[1]. |
| Target | IC50: 0.421 μM (AChE). |
| Invitro | AChE-IN-62 (50 μM; 24-48 h) 能有效抑制 Aβ1−42 的聚集，IC50 值为 44.64 μM[1]。AChE-IN-62 (5-20 μM; 24 h) 在 SH-SY5Y 和 Neuro2A 细胞中，能够改善 H2O2 (200 μM; 24 h) 和Okadaic acid (HY-N6785) (30 nM; 24 h) 介导的细胞神经毒性，具有神经保护作用[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> AChE-IN-62 相关抗体: Cell Viability Assay[1] Cell Line: |
| In Vivo | AChE-IN-62 (Compound 1) ( 10-20 mg/kg; 腹腔注射; 一天一次连续 7 天) 在瑞士白化痴呆小鼠中通过修复大脑皮层和海马组织的损伤来改善东莨菪碱 (HY-N0296) (3 mg/kg; 腹腔注射; 一天一次连续 7 天) 诱导的记忆力下降和学习障碍，对东莨菪碱造成的伤害起到了保护作用[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: |
| Formula | C19H21N5O3S2 |
| Molar Mass | 431.53 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Mishra CB, et al. Multitarget action of Benzothiazole-piperazine small hybrid molecule against Alzheimer's disease: In silico, In vitro, and In vivo investigation. Biomed Pharmacother. Published online April 1, 2024. |