| Bioactivity | AChE-IN-59 (compounds 3b) is an AChE inhibitor, with an IC50 value of 0.05 μM. AChE-IN-59 can inhibit the aggregation of Aβ1-42, protect nerve cells and penetrate the blood-brain barrier well. AChE-IN-59 can be used for the research of Alzheimer's disease (AD)[1]. |
| Invitro | AChE-IN-59 (compounds 3b) (50/100/500/1000 μg/ mL, 5 min) 可抑制 ChEs 的活性，其中对 AChE 和 BuChE 的 IC50 值分别为 0.05 μM 和 4.68 μM，表明 AChE-IN-59 对 AChE 亚型具有选择性[1]。AChE-IN-59 (50/100/500/1000 μg/ mL, 5 min) 在铁离子还原抗氧化能力 (FRAP) 和 DPPH 自由基清除能力的测试中表现出良好的体外抗氧化活性[1]。AChE-IN-59 (25 µM, 5 min) 对 SH‐SY5Y 细胞没有毒性作用[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> AChE-IN-59 相关抗体: Cell Viability Assay[1] Cell Line: |
| In Vivo | AChE-IN-59 (compounds 3b) (25 μM，3 天) 可以缓解 AlCl3 诱导的斑马鱼幼体运动迟缓的行为效应[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: |
| CAS | 2957916-86-6 |
| Formula | C25H28N2O6 |
| Molar Mass | 452.50 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Zhai J, et al. Design, synthesis, and evaluation of dual-target inhibitors for the treatment of Alzheimer's disease. Arch Pharm (Weinheim). 2024 Feb 8:e2300693. |
AChE-IN-59
CAS: 2957916-86-6 F: C25H28N2O6 W: 452.50
AChE-IN-59 (compounds 3b) is an AChE inhibitor, with an IC50 value of 0.05 μM. AChE-IN-59 can inhibit the aggregation o
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This product is for research use only, not for human use. We do not sell to patients.