| Bioactivity | AChE-IN-51 (compound 8C) is an orally active, non-competitive inhibitor of AChE and BChE (IC50: 84 nM, 97 nM). It also inhibits MMP-2 and amyloid Aβ1-42 aggregates (IC50: 724 nM, 302 nM). AChE-IN-51 has low cytotoxicity and in silico predicted blood-brain barrier permeability. Can be used for research on diseases such as Alzheimer's disease (AD)[1]. |
| Target | 84 nM (AChE), 97.04 nM (AChE), 724.19 nM (MMP-2), 302.36 nM (Aβ1-42 aggregation) |
| Name | AChE-IN-51 |
| Formula | C23H21OP |
| Molar Mass | 344.39 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. El-Hussieny M, et al. Dual-target ligand discovery for Alzheimer's disease: triphenylphosphoranylidene derivatives as inhibitors of acetylcholinesterase and β-amyloid aggregation. J Enzyme Inhib Med Chem. 2023 Dec;38(1):2166040. |