| Bioactivity | AChE-IN-21 (Compound I-8) is a potent, selective and orally active AChE inhibitor with an IC50 of 2.66 nM. AChE-IN-21 displays excellent BBB permeability in vitro[1]. |
| Invitro | AChE-IN-21 (Compound I-8) binds to both the catalytic active site and peripheral anionic site of AChE[1]. |
| In Vivo | AChE-IN-21 (Compound I-8) (0-25 mg/kg; i.g.; once a day for 7 consecutive days) significantly reverses scopolamine-induced memory deficit in mice[1]. Animal Model: |
| Name | AChE-IN-21 |
| CAS | 2413656-04-7 |
| Formula | C24H29NO4 |
| Molar Mass | 395.49 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Luo L, et al. Design, synthesis and evaluation of phthalide alkyl tertiary amine derivatives as promising acetylcholinesterase inhibitors with high potency and selectivity against Alzheimer's disease. Bioorg Med Chem. 2020 Apr 15;28(8):115400. |
AChE-IN-21
CAS: 2413656-04-7 F: C24H29NO4 W: 395.49
AChE-IN-21 (Compound I-8) is a potent, selective and orally active AChE inhibitor with an IC50 of 2.66 nM. AChE-IN-21 di
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