| Bioactivity | ACT-672125 is a potent CXCR3 antagonist with IC50 value of 239 nM in human blood. ACT-672125 has activity for hERG with IC50 value of 18μM. ACT-672125 can be used for the research of autoimmune diseases[1]. |
| Target | IC50: 239 nM (CXCR3); 18 μM (hERG). |
| Name | ACT-672125 |
| CAS | 1449367-94-5 |
| Formula | C25H25F3N10O2S |
| Molar Mass | 586.59 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Caroff E, et al. Design, Synthesis, and Pharmacological Evaluation of Benzimidazolo-thiazoles as Potent CXCR3 Antagonists with Therapeutic Potential in Autoimmune Diseases: Discovery of ACT-672125. J Med Chem. 2022 Sep 8;65(17):11533-11549. |
ACT-672125
CAS: 1449367-94-5 F: C25H25F3N10O2S W: 586.59
ACT-672125 is a potent CXCR3 antagonist with IC50 value of 239 nM in human blood. ACT-672125 has activity for hERG with
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