| Bioactivity | ACBI1 is a potent and cooperative SMARCA2, SMARCA4 and PBRM1 degrader with DC50s of 6, 11 and 32 nM, respectively. ACBI1 is a PROTAC degrader. ACBI1 shows anti-proliferative activity. ACBI1 induces apoptosis[1]. |
| Invitro | ACBI1 (1-10000 nM； 3-7 days) shows anti-proliferative activity[1].ACBI1 (0.3 µM; 100 h) induces apoptosis in SK-MEL-5 cells[1].ACBI1 is composed of a bromodomain ligand, a linker, and the E3 ubiquitin ligase von Hippel-Lindau[1]. Cell Proliferation Assay[1] Cell Line: |
| Name | ACBI1 |
| CAS | 2375564-55-7 |
| Formula | C49H58FN9O7S |
| Molar Mass | 936.10 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | -20°C, protect from light, stored under nitrogen *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen) |