| Bioactivity | AC1-IN-1 is a potent and selective Adenylyl cyclase type 1 (AC1) inhibitor with an IC50 of 0.54 µM. AC1-IN-1 displays modest antiallodynic effects in a mouse model of inflammatory pain. AC1-IN-1 has CNS activity[1]. | ||||||||||||
| Target | IC50: 0.54 µM (AC1) | ||||||||||||
| Invitro | AC1-IN-1 (compound 38; HEK293 cells; 30 µM, 1 hours) shows nontoxic to this human cell line[1]. Cell Cytotoxicity Assay[1] Cell Line: | ||||||||||||
| In Vivo | AC1-IN-1 (5.6 mg/kg; i.v.) displays modest, yet statistically significant, antiallodynic effects at 1 h post-treatment compared to the 0 min (allodynic) time point[1]. Animal Model: | ||||||||||||
| Name | AC1-IN-1 | ||||||||||||
| CAS | 2762422-55-7 | ||||||||||||
| Formula | C18H18FN5O2 | ||||||||||||
| Molar Mass | 355.37 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Scott JA, et al. Optimization of a Pyrimidinone Series for Selective Inhibition of Ca2+/Calmodulin-Stimulated Adenylyl Cyclase 1 Activity for the Treatment of Chronic Pain. J Med Chem. 2022; 65(6):4667-4686. |
AC1-IN-1
CAS: 2762422-55-7 F: C18H18FN5O2 W: 355.37
AC1-IN-1 is a potent and selective Adenylyl cyclase type 1 (AC1) inhibitor with an IC50 of 0.54 µM. AC1-IN-1 displays m
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