| Bioactivity | AC-VEID-CHO (TFA) is a peptide-derived caspase inhibitor and has potency of inhibition for Caspase-6, Caspase-3 and Caspase-7 with IC50 values of 16.2 nM, 13.6 nM and 162.1 nM, respectively. AC-VEID-CHO (TFA) can be used for the research of neurodegenerative conditions including Alzheimer’s and Huntington’s disease[1]. | ||||||
| Invitro | AC-VEID-CHO (TFA) has potency of inhibition for Caspase-6, Caspase-3 and Caspase-7 with IC50 values of 16.2 nM, 13.6 nM and 162.1 nM, respectively[1].Ac-VEID-CHO is predominantly excluded from accessing the intracellular environment (0.16% cellular accumulation) and lacks any activity with an IC50 value of ＞100 μM in the cellular assay[1]. AC-VEID-CHO (TFA) (also inactive in lamin degradation assay) is clearly able to inhibit VEIDase activity with an IC50 value of 0.49 μM when the membrane barrier is removed[1]. | ||||||
| Name | AC-VEID-CHO TFA | ||||||
| Formula | C24H37F3N4O11 | ||||||
| Molar Mass | 614.57 | ||||||
| Appearance | Solid | ||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||
| Storage | Sealed storage, away from moisture
*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |
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| Reference | [1]. Robert Mintzer, et al. A whole cell assay to measure caspase-6 activity by detecting cleavage of lamin A/C. PLoS One. 2012;7(1):e30376. |
AC-VEID-CHO TFA
CAS: F: C24H37F3N4O11 W: 614.57
AC-VEID-CHO (TFA) is a peptide-derived caspase inhibitor and has potency of inhibition for Caspase-6, Caspase-3 and Casp
Data collection：peptidedb@qq.com
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