| Bioactivity | AC-93253 is a selective, potent SIRT2 inhibitor. AC93253 can inhibit SIRT2 with an IC50 value of 6 μM. AC93253 can be used for the research of tumors[1]. |
| Invitro | AC93253 可抑制 SIRT1、SIRT2 和 SIRT3，IC50 值分别为 45.3 μM、6 μM 和 24.6 μM[1]。AC-93253（0、2、5、10 μM；16 h）显著增强微管蛋白、p53 和组蛋白 H4 的乙酰化[1]。AC-93253 对四种肿瘤细胞系表现出选择性细胞毒性，IC50 值范围为 10 - 100 nM[1]。AC-93253 显著触发细胞凋亡[1]。 Western Blot Analysis[1] Cell Line: |
| Name | AC-93253 |
| CAS | 108527-83-9 |
| Formula | C23H25IN2S |
| Molar Mass | 488.43 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Zhang, Yingjia et al. Identification of a small molecule SIRT2 inhibitor with selective tumor cytotoxicity. Biochemical and biophysical research communications vol. 386,4 (2009): 729-33. |