| Bioactivity | AC 187 is a potent and orally active amylin receptor antagonist with an IC50 of 0.48 nM and a Ki of 0.275 nM. AC 187 shows more selective for amylin receptor than calcitonin and CGRP receptors. AC 187 has neuroprotective effects[1][2]. |
| Invitro | AC 187 blocks amyloidβ protein (Aβ)-induced neurotoxicity. Treatment of cultures with AC 187 before exposure to Aβ results in significantly improved neuronal survival[1].AC187 attenuates the activation of initiator and effector caspases that mediate Aβ-induced apoptotic cell death[1]. |
| Name | AC 187 |
| CAS | 151804-77-2 |
| Sequence | Ac-Val-Leu-Gly-Lys-Leu-Ser-Gln-Glu-Leu-His-Lys-Leu-Gln-Thr-Tyr-Pro-Arg-Thr-Asn-Thr-Gly-Ser-Asn-Thr-Tyr-NH2 |
| Shortening | Ac-VLGKLSQELHKLQTYPRTNTGSNTY-NH2 |
| Formula | C127H205N37O40 |
| Molar Mass | 2890.25 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
AC 187
CAS: 151804-77-2 F: C127H205N37O40 W: 2890.25
AC 187 is a potent and orally active amylin receptor antagonist with an IC50 of 0.48 nM and a Ki of 0.275 nM. AC 187 sho
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