| Bioactivity | AC 187 TFA is a potent and orally active amylin receptor antagonist with an IC50 of 0.48 nM and a Ki of 0.275 nM. AC 187 TFA shows more selective for amylin receptor than calcitonin and CGRP receptors. AC 187 TFA has neuroprotective effects[1][2]. | ||||||
| Invitro | AC 187 blocks amyloidβ protein (Aβ)-induced neurotoxicity. Treatment of cultures with AC 187 before exposure to Aβ results in significantly improved neuronal survival[1].AC187 attenuates the activation of initiator and effector caspases that mediate Aβ-induced apoptotic cell death[1]. | ||||||
| Name | AC 187 TFA | ||||||
| Sequence | Ac-Val-Leu-Gly-Lys-Leu-Ser-Gln-Glu-Leu-His-Lys-Leu-Gln-Thr-Tyr-Pro-Arg-Thr-Asn-Thr-Gly-Ser-Asn-Thr-Tyr-NH2 | ||||||
| Shortening | Ac-VLGKLSQELHKLQTYPRTNTGSNTY-NH2 | ||||||
| Formula | C129H206F3N37O42 | ||||||
| Molar Mass | 3004.27 | ||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||
| Storage | Sealed storage, away from moisture
*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |
AC 187 TFA
CAS: F: C129H206F3N37O42 W: 3004.27
AC 187 TFA is a potent and orally active amylin receptor antagonist with an IC50 of 0.48 nM and a Ki of 0.275 nM. AC 187
Data collection：peptidedb@qq.com
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