| Bioactivity | ABI-231 hydrochloride is a potent orally bioavailable microtubule inhibitor with activity that interacts with the colchicine binding site. ABI-231 hydrochloride demonstrated significant inhibition of melanoma tumor growth with an average IC50 of 5.2 nM in melanoma and prostate cancer cell lines. Pharmacological screening of ABI-231 hydrochloride shows it has a low risk of potential side effects[1]. |
| CAS | 2635953-17-0 |
| Formula | C21H20ClN3O4 |
| Molar Mass | 413.85 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Structure-Guided Design, Synthesis, and Biological Evaluation of (2-(1 H-Indol-3-yl)-1 H-imidazol-4-yl)(3,4,5-trimethoxyphenyl) Methanone (ABI-231) Analogues Targeting the Colchicine Binding Site in Tubulin |
ABI-231 hydrochloride
CAS: 2635953-17-0 F: C21H20ClN3O4 W: 413.85
ABI-231 hydrochloride is a potent orally bioavailable microtubule inhibitor with activity that interacts with the colchi
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