| Bioactivity | ABBV-318 is a potent Nav1.7/ Nav1.8 blocker, with IC50s of 2.8 μM and 3.8 μM for hNav1.7 and hNav1.8, respectively. ABBV-318 can be used for the research of pain[1]. | |||||||||
| Name | ABBV-318 | |||||||||
| CAS | 1802848-94-7 | |||||||||
| Formula | C20H15F4N3O2 | |||||||||
| Molar Mass | 405.35 | |||||||||
| Appearance | Solid | |||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | |||||||||
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| Reference | [1]. Patel MV, et, al. Discovery of (R)-(3-fluoropyrrolidin-1-yl)(6-((5-(trifluoromethyl)pyridin-2-yl)oxy)quinolin-2-yl)methanone (ABBV-318) and analogs as small molecule Na v 1.7/ Nav1.8 blockers for the treatment of pain. Bioorg Med Chem. 2022 Jun 1;63:11674 |
ABBV-318
CAS: 1802848-94-7 F: C20H15F4N3O2 W: 405.35
ABBV-318 is a potent Nav1.7/ Nav1.8 blocker, with IC50s of 2.8 μM and 3.8 μM for hNav1.7 and hNav1.8, respectively. AB
Data collection：peptidedb@qq.com
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