| Bioactivity | ABBV-303 is a multi-specific NK cell antibody targeting c-Met designed based on TriNKET technology for natural killer (NK) cell redirection therapy. The ABBV-303 antibody consists of three functional arms, a single-chain variable fragment (scFV) targeting c-Met, a Fab arm targeting NKG2D, and an Fc fragment targeting NK cell CD16a[1]. |
| Invitro | ABBV-303 三个功能臂的详细介绍[1]：(1) 单链可变片段 (scFV)：基于 ABT-700 (HY-P99391) 的 scFV，也是 c-Met 靶向的抗体-药物偶联物 (ADCs) ABBV-400 和 Teliso-V 的共有片段；(2) Fab 臂：靶向 NKG2D，用于结合表达 NKG2D 的 NK 细胞和活化的 CD8+ T 细胞；(3) 常规 Fc 片段：异二聚体的 IgG1 Fc，靶向 NK 细胞上的 CD16a，还用于连接 ABBV-303 的其他两个功能臂。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> ABBV-303 相关抗体: |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Stone J, et al. Abstract ND01: ABBV-303: A novel NK and CD8 T cell engager specific for c-Met-expressing tumors[J]. Cancer Research, 2024, 84(7_Supplement): ND01-ND01. |