| Bioactivity | ABBV-154 is an anti-TNF antibody-drug conjugate (ADC). ABBV-154 is composed of the humanized antibody Adalimumab (HY-P9908) conjugated with a glucocorticoid receptor modulator (HY-137883). ABBV-154 can be used in studies of rheumatoid arthritis, Crohn's disease and polymyalgia rheumatica[1]. |
| In Vivo | ABBV-154 (ADC 11) (0-80 mg/kg；皮下注射；两周一次；13 周) 在食蟹猴中有良好的稳定性，DAR 稳定在 4.0[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Hobson AD, et al. Discovery of ABBV-154, an anti-TNF Glucocorticoid Receptor Modulator Immunology Antibody-Drug Conjugate (iADC). J Med Chem. 2023 Sep 14;66(17):12544-12558. |