AB21 hydrochloride_product_DataBase

Bioactivity	AB21 hydrochloride is a potent and selective S1R antagonist with Kis of 13, 102 nM for S1R and S2R. AB21 hydrochloride has the effect of reducing mechanical hypersensitivity[1].
Invitro	AB21 hydrochloride 在 S1R 放射性配体结合测定实验中，有或没有 Phenythoin (HY-B0448) 条件下测得的 Ki 值分别为 12 nM 和 14 nM[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> AB21 hydrochloride 相关抗体:
In Vivo	AB21 hydrochloride (20 mg/kg, s.c., 注射 Capsaicin (HY-10448) 前 30 分钟给药) 可逆转 Phenythoin (HY-B0448) 诱导的疼痛模型中的机械性超敏反应，并显示出比 BD1063 dhydrochloride (HY-18101A) 更高的效力[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model:
CAS	3026677-24-4
Formula	C23H29ClN2O
Molar Mass	384.94
Appearance	固体
Transport	Room temperature in continental US; may vary elsewhere.
Storage	4°C, sealed storage, away from moisture and light *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Reference	[1]. Dichiara M, et al. Synthesis, Computational Insights, and Evaluation of Novel Sigma Receptors Ligands. ACS Chem Neurosci. 2023 May 17;14(10):1845-1858.

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