| Bioactivity | A947 is a potent and selective SMARCA2 proteolysis-targeting chimera molecule (PROTAC). A947 also is a potent and moderately selective SMARCA2 degrader. A947 has binding affinity to the SMARCA2 bromodomain with a Kd value of 93 nM. A947 can be used for the research of cancer[1]. |
| Invitro | A947 has binding affinity to the SMARCA2 and SMARCA4 bromodomains with Kd values of 93 nM and 65 nM, respectively[1].A947 can potently degrade SMARCA2 in SW1573 cells with a DC50 value of 39 pM[1].A947 (100 nM, 500 nM) mediates ubiquitination and degradation of SMARCA2/4[1].A947 (0-500 nM) can inhibit growth of SMARCA4-mutant NSCLC cells[1]. Western Blot Analysis[1] Cell Line: |
| Name | A947 |
| CAS | 2378056-80-3 |
| Formula | C61H76N12O7S |
| Molar Mass | 1121.40 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
A947
CAS: 2378056-80-3 F: C61H76N12O7S W: 1121.40
A947 is a potent and selective SMARCA2 proteolysis-targeting chimera molecule (PROTAC). A947 also is a potent and modera
Data collection：peptidedb@qq.com
This product is for research use only, not for human use. We do not sell to patients.