| Bioactivity | A3AR agonist 1 (Compound 12) is an A3AR agonist (Ki: 25.8 nM). A3AR agonist 1 stimulates β-arrestin2 recruitment, with an EC50 value of 5.17 nM. A3AR agonist 1 can be used for research of inflammatory diseases, ischemia, cancer, neuropathic pain, liver diseases, etc[1]. |
| Name | A3AR agonist 1 |
| Formula | C28H34N6O6 |
| Molar Mass | 550.61 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Dilip K. Tosh, et al. First Potent Macrocyclic A3 Adenosine Receptor Agonists Reveal G-Protein and 尾-Arrestin2 Signaling Preferences. ACS Pharmacol. Transl. Sci. 2023, 6, 9, 1288鈥?305. |