| Bioactivity | A2AR/A2BR antagonist 1 (compound 7ai) has a dual antagonistic effect on A2AR/A2BR, with the IC50 values of 11.2 nM and 6.4 nM for A2AR and A2BR, respectively. A2AR/A2BR antagonist 1 promotes T cell-mediated cancer cell death[1]. |
| Invitro | A2AR/A2BR antagonist 1 (compound 7ai) (0.1, 1, 10 μM, 0-48 h) 可以逆转 NECA (HY-103173) 介导的免疫抑制，促进 OT-I CTL 细胞的激活和杀伤能力，从而发挥抗癌活性[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> A2AR/A2BR antagonist 1 相关抗体: Western Blot Analysis[1] Cell Line: |
| Formula | C24H17N9 |
| Molar Mass | 431.45 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Wang H, et al. Subtle Structural Changes across the Boundary between A2AR/A2BR Dual Antagonism and A2BR Antagonism: A Novel Class of 2-Aminopyrimidine-Based Derivatives. J Med Chem. 2024 Mar 28;67(6):5075-5092. |