| Bioactivity | A031 is a highly effective PROTAC androgen receptor (AR) degrader with an IC50 value less than 0.25 μM for AR protein degradation. A031 has an inhibitory effect on tumor growth in zebrafish with human prostate cancer (VCaP)[1]. |
| Invitro | A031 (0.125-1.000 μM) 对雄激素受体具有抑制作用，IC50 值小于 0.25 μM[1]。A031 (2 μM; 2-4.5 h) 可降低 VCaP 细胞系中雄激素受体蛋白水平[1]。 Western Blot Analysis[1] Cell Line: |
| In Vivo | A031 (2.8，8.3 和 25 μM；加入到培养溶液中，共五天) 能抑制斑马鱼中前列腺肿瘤的生长。1.19Pharmacokinetic Properties of A031 in Rats[1]. |
| Name | A031 |
| CAS | 2682255-44-1 |
| Formula | C50H61ClN10O7S |
| Molar Mass | 981.60 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Chen L, et al. Discovery of A031 as effective proteolysis targeting chimera (PROTAC) androgen receptor (AR) degrader for the treatment of prostate cancer. Eur J Med Chem. 2021 Apr 15;216:113307. |