| Bioactivity | A-953227 is a highly potent and selective inhibitor with the activity of inhibiting calcium-dependent esterase (calpain). A-953227 has enhanced selectivity for related cysteine proteases (cathepsins) and has shown good efficacy in cell experiments. A-953227 has shown broad efficacy in preclinical models for Alzheimer's disease, suggesting that it has potential benefits in inhibiting Alzheimer's disease[1]. |
| CAS | 1037826-77-9 |
| Formula | C25H20FN5O3 |
| Molar Mass | 457.46 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Discovery of Novel and Highly Selective Inhibitors of Calpain for the Treatment of Alzheimer's Disease: 2-(3-Phenyl-1H-pyrazol-1-yl)-nicotinamides |
A-953227
CAS: 1037826-77-9 F: C25H20FN5O3 W: 457.46
A-953227 is a highly potent and selective inhibitor with the activity of inhibiting calcium-dependent esterase (calpain)
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