| Bioactivity | A 71915 is a highly potent and competitive natriuretic peptide receptor A (ANP, NPRA) antagonist (pKi= 9.18). A 71915 displaces [125I]ANP dose dependently, with a Ki of 0.65 nM. A71915( pA2= 9.48) against rat ANP-induced cGMP production in NB-OK-1 cells[1]. | ||||||
| Invitro | A 71915 combines to Neuroblastoma NB-OK-1 cells, is used in the Cyclic GMP assay.A 71915 shifts the ANP dose-response curve of cyclic GMP production to the right[1]. | ||||||
| Name | A 71915 | ||||||
| CAS | 132956-87-7 | ||||||
| Sequence | Arg-Cys-Cha-Gly-Gly-Arg-Ile-Asp-Arg-Ile-D-tic-Arg-Cys-NH2 (Disulfide bridge: Cys2-Cys13) | ||||||
| Shortening | {RC-Cha}-GGRIDRI-{D-Tic-RC}-NH2 (Disulfide bridge: Cys2-Cys13) | ||||||
| Formula | C69H116N26O15S2 | ||||||
| Molar Mass | 1613.95 | ||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||
| Storage | Sealed storage, away from moisture and light, under nitrogen
*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen) |
A 71915
CAS: 132956-87-7 F: C69H116N26O15S2 W: 1613.95
A 71915 is a highly potent and competitive natriuretic peptide receptor A (ANP, NPRA) antagonist (pKi= 9.18). A 71915 di
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