| Bioactivity | A-1293201 is a substrate-independent NAMPT inhibitor with antitumor activity. A-1293201 effectively reduces the total cellular NAD+/NADH (NADt) level, subsequently leading to ATP depletion and cancer cell death. In addition, A-1293201 can effectively overcome the acquired resistance mechanism of the NAMPT Y18 mutant to CHS-828 (HY-10079)[1]. |
| CAS | 1375557-33-7 |
| Formula | C21H23N3O3 |
| Molar Mass | 365.43 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Jun Guo, et al. "Identification of novel resistance mechanisms to NAMPT inhibition via the de novo NAD+ biosynthesis pathway and NAMPT mutation." Biochemical and biophysical research communications 491.3 (2017): 681-686. |
A-1293201
CAS: 1375557-33-7 F: C21H23N3O3 W: 365.43
A-1293201 is a substrate-independent NAMPT inhibitor with antitumor activity. A-1293201 effectively reduces the total ce
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