| Bioactivity | A-1208746 is an inhibitor for MCL-1, with a Ki of 0.454 nM. A-1208746 activates caspase-3/-7, induces apoptosis in cell H929, and decreases mitochondrial membrane potential. A-1208746 synergies with Navitoclax (HY-10087), and can be used in cancer research[1]. |
| Target | Ki: 0.454 nM (MCL-1) |
| CAS | 1668553-23-8 |
| Formula | C45H52N6O7S |
| Molar Mass | 821.00 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Leverson JD, et al., Potent and selective small-molecule MCL-1 inhibitors demonstrate on-target cancer cell killing activity as single agents and in combination with ABT-263 (navitoclax). Cell Death Dis. 2015 Jan 15;6(1):e1590. |
A-1208746
CAS: 1668553-23-8 F: C45H52N6O7S W: 821.00
A-1208746 is an inhibitor for MCL-1, with a Ki of 0.454 nM. A-1208746 activates caspase-3/-7, induces apoptosis in cell
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This product is for research use only, not for human use. We do not sell to patients.