| Bioactivity | A-1155905 is a MCL-1 inhibitor (IC50=0.0335 μM) with anticancer activity. A-1155905 selectively binds to MCL-1 with sufficient affinity to disrupt the MCL-1-bim complex in living cells. A-1155905-induced death of MCL-1-dependent cell lines is caspase-dependent and occurs via apoptosis[1]. |
| CAS | 2228052-37-5 |
| Formula | C46H51FN6O6 |
| Molar Mass | 802.93 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Leverson, et al. "Potent and selective small-molecule MCL-1 inhibitors demonstrate on-target cancer cell killing activity as single agents and in combination with ABT-263 (navitoclax)." Cell death & disease 6.1 (2015): e1590-e1590. |
A-1155905
CAS: 2228052-37-5 F: C46H51FN6O6 W: 802.93
A-1155905 is a MCL-1 inhibitor (IC50=0.0335 μM) with anticancer activity. A-1155905 selectively binds to MCL-1 with suf
Sales Email：peptidedb@qq.com
This product is for research use only, not for human use. We do not sell to patients.