| Bioactivity | A 1120 is a high-affinity nonretinoid retinol-binding protein 4 (RBP4) antagonist with a Ki value of 8.3 nM. A 1120 disrupts the interaction between RBP4 and its binding partner transthyretin[1][2]. | ||||||||||||
| Target | Ki: 8.3 nM (Retinol-binding protein 4) | ||||||||||||
| Invitro | The IC50 of A 1120 is 90 nM on human RBP4 and 66 nM on mouse RBP4[1]. | ||||||||||||
| Name | A 1120 | ||||||||||||
| CAS | 1152782-19-8 | ||||||||||||
| Formula | C20H19F3N2O3 | ||||||||||||
| Molar Mass | 392.37 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Motani A, et al. Identification and characterization of a non-retinoid ligand for retinol-binding protein 4 which lowers serum retinol-binding protein 4 levels in vivo. J Biol Chem. 2009 Mar 20;284(12):7673-80. [2]. Dobri N, et al. A1120, a nonretinoid RBP4 antagonist, inhibits formation of cytotoxic bisretinoids in the animal model of enhanced retinal lipofuscinogenesis. Invest Ophthalmol Vis Sci. 2013 Jan 7;54(1):85-95. |
A 1120
CAS: 1152782-19-8 F: C20H19F3N2O3 W: 392.37
A 1120 is a high-affinity nonretinoid retinol-binding protein 4 (RBP4) antagonist with a Ki value of 8.3 nM. A 1120 disr
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