| Bioactivity | 8A8 is a potent proinflammatory factor NO inhibitor with an IC50 of 4.7 μM. 8A8 also significantly inhibits LPS-induced HaCat cell proliferation[1]. |
| Invitro | Low concentrations of compound 8A8 (2.5 μM; RAW 264.7 cells) could significantly down-regulate IL-6 and TNF-α in cellular emotional intelligence, IL-6 and TNF-α are only half of those after LPS treatment at 5 μM, and IL-6 and TNF-α in cell supernatants were only a quarter of those after LPS treatment after high concentration compound 8A8 (10 μM)[1]. |
| Name | 8A8 |
| Formula | C36H37BrClN5O9 |
| Molar Mass | 799.06 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Zhang F, et al. Design and synthesis of the 4H-chromenone derivatives against psoriasis [published online ahead of print, 2022 Jan 25]. Bioorg Chem. 2022;120:105640. |