| Bioactivity | 84-B10 is a 3-phenylglutaric acid derivative. 84-B10 inhibits cisplatin (HY-17394) induced tubular ferroptosis. 84-B10 attenuates cisplatin-induced mitochondrial damage and oxidative stress. 84-B10 ameliorates cisplatin-induced acute kidney injury (AKI)[1]. | ||||||||||||
| Invitro | 84-B10 (10-100 μM; 2 h) 以剂量依赖性方式抑制顺铂诱导的肾小管上皮细胞铁死亡[1]。84-B10 (40 μM; 2 小时; TKPT 细胞) 恢复顺铂诱导的线粒体结构损伤和功能障碍[1]。84-B10 (40 μM; 2 小时; TKPT 细胞) 减轻顺铂诱导的 AKI 中 mtROS 诱导的氧化应激[1]。84-B10 (40 μM; 2 小时; TKPT 细胞) 通过消除 mtROS 和恢复线粒体稳态来减轻顺铂诱导的上皮细胞损伤[1]。 Western Blot Analysis[1] Cell Line: | ||||||||||||
| In Vivo | 84-B10 (5-15 mg/kg; i.p.) 减轻顺铂诱导的小鼠急性肾损伤[1]。 Animal Model: | ||||||||||||
| Name | 84-B10 | ||||||||||||
| CAS | 698346-43-9 | ||||||||||||
| Formula | C25H22F3NO5 | ||||||||||||
| Molar Mass | 473.44 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Fan J, et, al. A novel 3-phenylglutaric acid derivative (84-B10) alleviates cisplatin-induced acute kidney injury by inhibiting mitochondrial oxidative stress-mediated ferroptosis. Free Radic Biol Med. 2023 Jan;194:84-98. |