| Bioactivity | 8-OAc is a potent and selective mitochondrial electron transport chain (ETC) complex I inhibitor. 8-OAc exhibits cytotoxicity against cancer cell lines[1]. |
| Invitro | 8-OAc (5-100 μM；24 小时) 可以优先靶向癌细胞以启动细胞死亡途径，同时对非癌细胞的生存力影响最小。8-OAc 可诱导 ROS 生成，导致肝癌细胞死亡[1]。8-OAc 能够在秀丽隐杆线虫中产生线粒体兴奋效应，并延长成虫寿命。8-OAc 需要 HSF1 介导热休克反应 (HSR) 通路[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> 8-OAc 相关抗体: Cell Viability Assay[1] Cell Line: |
| CAS | 2550395-87-2 |
| Formula | C24H34N2O4S |
| Molar Mass | 446.60 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Naibedya Dutta, et al. Investigating impacts of the mycothiazole chemotype as a chemical probe for the study of mitochondrial function and aging. Geroscience. 2024 Apr 3. |