| Bioactivity | 8-Mercaptoguanosine is an immunoadjuvant that affects the in vivo antibody response to the T-cell-independent antigen TNP-Ficoll. 8-Mercaptoguanosine enhances IgG1, IgG2, and IgG3 antibody responses, but has no effect on IgM antibody responses. 8-Mercaptoguanosine also enhances antibody responses to very weak antigens such as pneumococcal polysaccharide and restores antibody responses in immunodeficient xid mice that are non-reactive to TNP-Ficoll[1][2]. |
| CAS | 26001-38-7 |
| Formula | C10H13N5O5S |
| Molar Mass | 315.31 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Mond JJ, Hunter K, Kenny JJ, Finkelman F, Witherspoon K. 8-Mercaptoguanosine-mediated enhancement of in vivo IgG1, IgG2 and IgG3 antibody responses to polysaccharide antigens in normal and xid mice. Immunopharmacology. 1989 Nov-Dec;18(3):205-12. [2]. Feldbush TL, Ballas ZK. Lymphokine-like activity of 8-mercaptoguanosine: induction of T and B cell differentiation. J Immunol. 1985 May;134(5):3204-11. |
8-Mercaptoguanosine
CAS: 26001-38-7 F: C10H13N5O5S W: 315.31
8-Mercaptoguanosine is an immunoadjuvant that affects the in vivo antibody response to the T-cell-independent antigen TN
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