| Bioactivity | 8-Hydroxyefavirenz (8-OH-EFV) is a primary metabolite of Efavirenz (HY-10572). 8-Hydroxyefavirenz induces apoptosis via a JNK- and BimEL-dependent mechanism in primary human hepatocytes. 8-Hydroxyefavirenz can be used in research of cancer[1]. |
| Invitro | 8-Hydroxyefavirenz (8-OH-EFV; 1-10 μM; 3-24 h; 原代人肝细胞) 以时间和浓度依赖的方式增加细胞死亡，并从 6 小时开始诱导 caspase-3 活性[1]。8-Hydroxyefavirenz (1-10 μM; 6-24 h) 刺激原代人肝细胞中线粒体 ROS 的产生[1]。8-Hydroxyefavirenz (10 μM; 3-24 h) 激活 JNK 并使磷酸化的 JNK 占总 JNK 的比例增加 4.2 倍。8-Hydroxyefavirenz 增加 BimEL mRNA 和蛋白表达[1]。 Cell Viability Assay[1] Cell Line: |
| Name | 8-Hydroxyefavirenz |
| CAS | 205754-33-2 |
| Formula | C14H9ClF3NO3 |
| Molar Mass | 331.67 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
8-Hydroxyefavirenz
CAS: 205754-33-2 F: C14H9ClF3NO3 W: 331.67
8-Hydroxyefavirenz (8-OH-EFV) is a primary metabolite of Efavirenz (HY-10572). 8-Hydroxyefavirenz induces apoptosis via
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