| Bioactivity | 8-Bromoguanosine is a purine nucleoside, a brominated derivative of guanosine. 8-Bromoguanosine can reduce the conformational heterogeneity of RNA to enhance its function[1][2][3]. |
| Invitro | 8-Bromoguanosine (16-18 h) induces cytotoxic activity to YAC cells[2].8-Bromoguanosine (18 h) induces macrophage cytolytic activity to P815 cells[2]. |
| Name | 8-Bromoguanosine |
| CAS | 4016-63-1 |
| Formula | C10H12BrN5O5 |
| Molar Mass | 362.14 |
| Appearance | Solid |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | -20°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light) |
| Reference | [1]. Goodman MG, Weigle WO. Intracellular lymphocyte activation and carrier-mediated transport of C8-substituted guanine ribonucleosides. Proc Natl Acad Sci U S A. 1984 Feb;81(3):862-6. [2]. Koo GC, Jewell ME, Manyak CL, Sigal NH, Wicker LS. Activation of murine natural killer cells and macrophages by 8-bromoguanosine. J Immunol. 1988 May 1;140(9):3249-52. [3]. Yajima R, et al. A conformationally restricted guanosine analog reveals the catalytic relevance of three structures of an RNA enzyme. Chem Biol. 2007 Jan;14(1):23-30. |
8-Bromoguanosine
CAS: 4016-63-1 F: C10H12BrN5O5 W: 362.14
8-Bromoguanosine is a purine nucleoside, a brominated derivative of guanosine. 8-Bromoguanosine can reduce the conformat
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