| Bioactivity | 8-Bromoadenine (8-Bromo-9H-purin-6-amine) is a DNA radiosensitizer that inhibits DNA single-strand break repair in cells. 8-Bromoadenine is a brominated derivative of adenine, and radioactive adenine can be prepared by replacing bromine with deuterium[1][2]. |
| Invitro | 8-Bromoadenine (0.1 mM; 30-90 min) 能抑制 HeLa-M 细胞单层培养物中的 DNA 单链断裂修复。且经 γ 照射后，细胞合成的 DNA 的质量比无嘌呤添加时细胞合成的 DNA 治疗更低[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> 8-Bromoadenine 相关抗体: |
| CAS | 6974-78-3 |
| Formula | C5H4BrN5 |
| Molar Mass | 214.02 |
| Appearance | 固体 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | 4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light) |
| Reference | [1]. Tkalich A V, et al. Effect of 8-bromoadenine on DNA repair[J]. Tsitologiia, 1980, 22(8): 994-997. [2]. Radioactively marked nucleic acid units. German Democratic Republic, DD106383 A1 1974-06-12. |
8-Bromoadenine
CAS: 6974-78-3 F: C5H4BrN5 W: 214.02
8-Bromoadenine (8-Bromo-9H-purin-6-amine) is a DNA radiosensitizer that inhibits DNA single-strand break repair in cells
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